Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature

Thyrotoxic Periodic Paralysis: Case Reports and an Up-to-Date Review of the Literature

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Objectives.To describe 2 cases of thyrotoxic periodic paralysis.Methods.We report of 2 cases of thyrotoxic periodic donjoy iceman shoulder wrap paralysis in 2 individuals from 2 different backgrounds with emphasis on their presentation and treatment.

We also conducted a literature search to put together an update review of thyrotoxic periodic paralysis.Results.A 47-year-old Chinese and 28-year-old Caucasian male presented with profound yet reversible weakness associated with hypokalemia on admission bloods and thyrotoxicosis.Both were given definitive therapy to prevent recurrence of milwaukee 2981-20 attacks with any future relapse of thyrotoxicosis.

Conclusion.Thyrotoxic periodic paralysis (TPP) is a rare but potentially serious complication of thyrotoxicosis resulting in temporary but severe muscle weakness.Recent discovery of a novel mutation in the KCNJ18 gene which codes for an inwardly rectifying potassium channel and is controlled by thyroid hormones may provide greater insight into the pathogenesis of TPP.